Imidodicarbonic acid, 2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-, 1,3-bis(1,1-dimethylethyl) ester
2-(N,N-BisBOC-Amino)pyrimidine-5-boronic acid, pinacol ester
CAS: 1190423-36-9
Molecular Formula: C20H32BN3O6
Imidodicarbonic acid, 2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-, 1,3-bis(1,1-dimethylethyl) ester - Names and Identifiers
Imidodicarbonic acid, 2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-, 1,3-bis(1,1-dimethylethyl) ester - Physico-chemical Properties
| Molecular Formula | C20H32BN3O6 |
| Molar Mass | 421.3 |
| Density | 1.15±0.1 g/cm3(Predicted) |
| Boling Point | 498.3±37.0 °C(Predicted) |
| pKa | -0.76±0.10(Predicted) |
| Storage Condition | under inert gas (nitrogen or Argon) at 2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD12913985 |
Imidodicarbonic acid, 2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-, 1,3-bis(1,1-dimethylethyl) ester - Introduction
2-(N,N-diBOC-ammonia) pyrimidine-5-boronic acid pinacol ester is an organic compound whose chemical formula is C16H24BN3O6.
Nature:
-Appearance: It is a white crystalline solid.
-Melting point: Its melting point range is usually between 100-105°C.
-Solubility: It is soluble in common organic solvents (such as ether, dichloromethane, etc.).
Use:
- 2-(N,N-diBOC-amino) pyrimidine -5-boronic acid pinacol ester is a common chemical intermediate, which has a wide range of applications in the field of organic synthesis.
-It can be used to prepare a variety of pyrimidine derivatives, such as drugs, natural products and agricultural chemicals.
Preparation Method:
The preparation of pinacol ester of -2-(N,N-diBOC-amino) pyrimidine -5-boronic acid is generally accomplished by a reaction sequence. First, an amino protecting group (e. g., a BOC group) is esterified with pyrimidine-5-boronic acid to produce 2-(N,N-diBOC-ammonia) pyrimidine-5-boronate. This ester is then subjected to an alcoholysis reaction with pinacol to give the final product.
Safety Information:
The safety and acute toxicity of -2-(N,N-diBOC-ammonia) pyrimidine-5-boronic acid pinacol ester have not been fully established.
-When handling and handling, follow laboratory safety regulations, avoid direct contact with skin and eyes, and use personal protective equipment appropriately.
-During storage, avoid dangerous substances such as high temperature, fire source and strong oxidant.
Nature:
-Appearance: It is a white crystalline solid.
-Melting point: Its melting point range is usually between 100-105°C.
-Solubility: It is soluble in common organic solvents (such as ether, dichloromethane, etc.).
Use:
- 2-(N,N-diBOC-amino) pyrimidine -5-boronic acid pinacol ester is a common chemical intermediate, which has a wide range of applications in the field of organic synthesis.
-It can be used to prepare a variety of pyrimidine derivatives, such as drugs, natural products and agricultural chemicals.
Preparation Method:
The preparation of pinacol ester of -2-(N,N-diBOC-amino) pyrimidine -5-boronic acid is generally accomplished by a reaction sequence. First, an amino protecting group (e. g., a BOC group) is esterified with pyrimidine-5-boronic acid to produce 2-(N,N-diBOC-ammonia) pyrimidine-5-boronate. This ester is then subjected to an alcoholysis reaction with pinacol to give the final product.
Safety Information:
The safety and acute toxicity of -2-(N,N-diBOC-ammonia) pyrimidine-5-boronic acid pinacol ester have not been fully established.
-When handling and handling, follow laboratory safety regulations, avoid direct contact with skin and eyes, and use personal protective equipment appropriately.
-During storage, avoid dangerous substances such as high temperature, fire source and strong oxidant.
Last Update：2024-04-09 21:01:54
![Imidodicarbonic acid, 2-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyrimidinyl]-, 1,3-bis(1,1-dimethylethyl) ester](http://res.chembk.com/assets/images/structure/1190423-36-9.gif)